Did you know that more than 1000 medications and herbal preparations can be associated with liver damage (hepatotoxicity)? It manifests as hepatitis or as a laboratory abnormality. In the United States, medications, primarily acetaminophen, are the most common cause of acute liver failure. Worldwide, the antibiotic amoxicillin + clavulanic acid ranks first in terms of the frequency of liver damage.

All substances we ingest enter the liver, where they are classified as toxins or other molecules.

On the LiverTox website (https://livertox.nih.gov/), you can find a database containing all medications and dietary supplements that can cause liver damage.

What are the risk factors?

Risk factors for drug-induced liver damage may include:

  • Concurrent use of multiple medications 
  • Uncontrolled alcohol consumption
  •  Poor nutritional status and consumption of certain foods 
  • Age and gender 
  • Pre-existing liver disease 
  • Genetic predisposition
Please note that alcohol and food in combination with certain medications can contribute to liver damage.

Paracetamol – the most commonly used fever and pain relief medication worldwide 

When it comes to medications, paracetamol is one of the most common causes of self-poisoning. Long-term use of doses exceeding 4 g per day leads to reversible elevation of liver transaminases. Taking single high doses results in significant increases in enzymes and, ultimately, liver failure and death.

Hepatotoxicity of antibiotics 

In addition to paracetamol, the antibiotic amoxicillin + clavulanic acid is one of the most common causes of hepatotoxicity in Europe. Liver damage occurs several days to 8 weeks after the start of therapy and is characterized by symptoms such as fatigue, nausea, abdominal pain, itching, jaundice, and slightly elevated body temperature.

Follow these 3 golden rules and preserve your liver

  1. 1. I know you don’t like to hear “avoid alcohol” – it can sound like a ban on good fun. The liver is particularly sensitive to alcohol, so regularly detoxify your liver from toxins generated by the breakdown of alcohol (and other substances) in the liver. 
  2. 2. Balance your lifestyle – physical activity, healthy diet, positive attitude. 
  3. 3. Consult a medication specialist – a pharmacist – for the use of medications and dietary supplements. Although “the neighbor always knows best”. The liver is the largest gland and the second-largest organ in our body, responsible for over 500 vital functions, our main “laboratory”. It is also the only internal organ with the ability to regenerate.

DAMASALIS has developed a product for the health of your liver, with a unique composition and a 7-in-1 action:

SILYSMART contains a phytosomal form of milk thistle extract that our body can better utilize, resulting in a 7 times stronger absorption compared to conventional products on the market – it regenerates and protects the liver, cleanses the body from free radicals and toxins from medications, supports the liver and gallbladder in fat digestion, slows down the growth of tumor cells, protects against oxidative stress, reduces fatigue, and restores energy.

  • Reduced glutathione, the strongest antioxidant in our body, which further protects the liver from accumulated toxins 
  • Choline bitartrate promotes fat breakdown and supports liver function 
  • Vitamin E protects liver cells from oxidative stress

The liver doesn’t cause pain, but we cannot survive without it! Pay attention to the symptoms of an overloaded liver and take immediate action

*Product results may vary from person to person and may differ from those described on the website.


  1. Féher J, Lengyel G. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7.
  2. www.researchgate.net/figure/Difference-between-phytosome-and-liposome-The-molecular-organization-of-phytosomes_fig1_230727931
  3. R Aller ,O Izaola,S Gómez,C Tafur,G González,E Berroa,N MoraJ M González,D A de Luis: Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. Eur Rev Med Pharmacol Sci. 2015 Aug;19(16):3118-24.
  4. www.kardio.hr

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